Tuesday, 28th November The Australasian Society for Immunology 2017 Annual Scientific Meeting

• Anti-tumor T cells- you are what you eat - Susan Kaech
• TACI signaling: A novel immune checkpoint in Chronic Lymphocytic Leukaemia - Fabienne Mackay
• The immunological synapse and the structure of T cell communication - Michael Dustin
• Deciphering resident memory T cell ontogeny - Laura Mackay

• CRISPR-Cas9 screens for novel immune checkpoint in human NK cells - Nicholas Huntington
• Dendritic cell plasticity and CD4+ helper T cell responses - Franca Ronchese
• Photoconversion and in vivo imaging shed light on immune cell migration and function in inflammation and cancer - Tatyana Chtanova
• Epigenetic control of innate and adaptive immune memory - Joseph Sun

• Strong immunogenicity of membrane nanovesicles from dendritic cells - Jonathan Sprent
• Using Primary Immunodeficiencies to Investigate Human CD4⁺ T cell Development, Differentiation and Function. - Cindy Ma
• A direct analysis of viral epitope abundance and its impact on an endogenous antiviral CTL immunodominance hierarchy - Nicole L La Gruta
• Chimeric Antigen Receptor T cells: Priming, Cytotoxicity and the immune synapse - Misty Jenkins

Sponsored by 

Chair
Corey Smith,
QIMR Berghofer Medical Research Institute, Brisbane

Agenda
Manufacturing CAR T cells for treatment of solid tumours
Tessa Gargett,
Centre for Cancer Biology, University of South Australia, Adelaide

Regulatory T cells for clinical application – meeting the challenges
Siok Tey,
QIMR Berghofer Medical Research Institute, Brisbane

• The transcription factor Pax5 organises the B cell genome in three-dimensions - Timothy M Johanson
• Histone and DNA methylation changes in KMT2D mutant mice result in an expanded LSK progenitor population and a B cell-intrinsic expansion of the germinal centre reaction - Etienne Masle-Farquhar
• The role of histone-modifying complexes in regulating B cell responses to infection - Kim L Good-Jacobson
• Distinct mechanisms govern tissue-resident memory T cell development in different organs - Erica Wynne-Jones
• A discrete T cell receptor repertoire is censored at wave 1 of thymic selection - Stephen Daley
• Pre-configured chromatin loops and enhancer poising underscores effector cd8⁺ t cell differentiation - Brendan E. Russ
• The role of microbiota in the formation of circulating memory CD8⁺ T cells - Annabell Bachem

• A primary controlled human malaria infection uniquely activates CD16⁺ blood dendritic cells - Jessica R Loughland
• Human Plasmodium falciparum infection induces a predictable and persistent distortion in transcriptomic landscapes across T cell subsets - Thomas S Watkins
• Murine cytomegalovirus spreads by dendritic cell recirculation - Helen Farrell
• Role of Adrenoreceptor Signaling on Lymphocyte Migration - Sapna Devi
• Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasome in alphavirus-induced inflammation - Ali Zaid
• Differential utilisation of zinc by macrophages as an antimicrobial weapon against intracellular bacteria - Claudia J Stocks
• Immune surveillance by a contiguous network of monocyte-derived macrophages residing in the hepatic capsule - Frederic Sierro

• Impact of elevated sympathetic neural signaling on anti-cancer immunity and immunotherapy - Stephen Mattarollo
• Efficacy of neoadjuvant immunotherapy is mediated through the selective expansion of tumour-specific CD8⁺ T cells with a memory precursor phenotype - Michele W Teng
• The Complement C3a Receptor: a Novel Therapeutic Target for Melanoma? - Barbara E Rolfe
• TACI deletion ameliorates immune dysfunction in Chronic Lymphocytic Leukaemia - Beatriz Garcillan
• A multifunctional role for adjuvant anti-4-1BB therapy in augmenting anti-tumour responses by chimeric antigen receptor T cells - Sherly Mardiana
• Targeting the tumour microenvironment to enhance immunotherapy against cancer - Amanda J Oliver
• CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity - Marian L Burr

• Development and diversity of mr1-restricted t cells - Dale Godfrey
• MAIT cells: friend or foe? Role in H. pylori induced gastritis - Criselle Dsouza
• Enteric microbiota shape the inflammatory response in mice with a Muc2 misfolding mutation - Ran Wang
• HMGB1 amplifies ILC2 cytokine production and mediates ILC2-induced airway smooth muscle remodelling during severe viral bronchiolitis and subsequent asthma - Md Ashik Ullah
• A role for early oral exposure to house dust mite in food allergy susceptibility - Valerie verhasselt
• Pathogenic NKT cells attenuate clearance and exacerbate disease in urogenital chlamydial infections - Charles W Armitage
• Molecular control of tissue-resident regulatory T cell differentiation - Axel Kallies

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity - Christina Sparbier

• CD83 is a promising biomarker and therapeutic target in Hodgkin Lymphoma - Edward Abadir
• The role of chemokine receptors in metastatic cancer - Caitlin Abbott
• The role of T cells in ovarian cancer - Farah FA Ahmady
• The effect of STING deficiency on development of autoimmune diabetes in NOD mice - Satoru Akazawa
• The pathological role of the inflammasome protein asc in parkinson’s disease - Eduardo A Albornoz
• Systemic inflammatory signals suppress local lymph node expansion and B cell immunity - Yannick O Alexandre
• Recognition of non-lipid antigens by Type 2 NKT cells - Catarina Filipa dos Santos Sa e Almeida
• Complete freund’s adjuvant a cheap and effective novel anticancer immunotherapy - Erin R. Andrew
• The role of chemokine receptor CXCR3 in the T cell response in the lung following pulmonary immunization with a recombinant Influenza A tuberculosis vaccine - Ellis Armitage
• Mesenchymal stromal cell infusion rapidly attenuates systemic inflammation in patients with chronic obstructive pulmonary disease   - Jesse D Armitage
• CXCR6 deficiency alters control of chronic Mycobacterium tuberculosis infection and the inflammatory kinetics of acute respiratory infection - Anneliese S Ashhurst
• Effects of dexamethasone co-medication on chemo-immunotherapy treatment in murine cancer models - Wayne J Aston
• RNA binding protein HuR is required for efficient function and generation of CD4⁺ Foxp3⁺ Treg - Ulus Atasoy
• The impact of prior immunity on seasonal influenza vaccine responses in an influenza vaccine-naïve Vietnamese cohort - Maria Auladell Bernat
• Designing a structured, data driven, high complexity human multi-color flow cytometric panel - Robert Balderas
• Investigation of Mast Cell Toll-like receptor 3 in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Systemic Mastocytosis patients using the novel application of autoMACS magnetic separation and Flow cytometry - Cassandra Balinas
• Investigation of endocannabinoid-based nanoassemblies targeted to the synovium for the treatment of arthritis - Nicola Barrie
• IS ZEB2 involved in lineage commitment of the human Th1/17  subset,  and why does FOXP3 repress it in Treg? - Simon C Barry
• Lymphocyte-dependent reduction of MHC class II expression on dendritic cells from Human papillomavirus E7 transgenic mice - Abate Bashaw
• Dissecting the relative contributions of resident macrophages and infiltrating monocytes to the control of hepatic Leishmania infection - Lynette Beattie
• Targeting local tumour immunosuppression to enhance chimeric antigen receptor T Cell efficacy in solid cancers - Paul A Beavis
• GILZ: A new regulator of CD8 T cell responses  - Taylah J Bennett
• Phenotypic Differences in Peripheral Blood Immune Cells: Contrasting Progressive Multiple Sclerosis with Healthy Controls - Carl Beyers
• Intracellular bacterial infection promotes the expansion of Tfh1 and B-cell populations - Nayan Bhattacharyya
• A novel mouse model of a human primary immunodeficiency: new insights into the role of PI3K in T cell activation and differentiation - Julia Bier
• Regulatory T cell control of T cell reconstitution in a model of bone marrow transplantation  - Holly Bolton
• Caveolin-1 is enriched in CD8+ T cell exosomes, influencing cholesterol homeostasis and intracellular uptake - Jessica Borger
• Regulation of inflammatory caspase activity during the innate immune response - Dave Boucher
• Retinoic acid-dependent expression of Hic1 in T cells links Myc-dependent metabolism with the tissue residency gene program - Michael Bramhall
• Characterising self-reactive B cell responses within a polyclonal repertoire - Jeremy F Brooks
• A blood dendritic cell vaccine expands anti-tumour T cell responses in AML - Christian Bryant
• Liposomal delivered antigen-specific tolerising immunotherapy targeting autoreactive CD8+ T cells in NOD mice - Irina Buckle
• Antibodies cross reacting with self and foreign proteins evolve on consistent trajectories to shed self-binding and then enhance foreign binding - Deborah Burnett
• IFNα subtypes drive distinct anti-cancer activities - Anthony Buzzai
• Viral infection of NK cells drives a mature phenotype but inhibits cytolytic function - Tessa M Campbell
• Differential immune responses between animals that clear Group B Streptococcal genital infection and those that remain colonised - Alison J Carey
• Defining skin-resident T cells in mouse and human - Clara Castellucci
• Elevated serum IgG3 is associated with accelerated progression from clinically isolated syndrome to multiple sclerosis - Lilian Cha
• Dysregulated IL-21-mediated phosphorylation and nuclear translocation of STAT3 in B-cells of HIV-infected individuals may be associated with increased IFN-α activity - Lilian Cha
• Characterisation of naïve influenza-specific TCR repertoires in human cord blood - Jesseka Chadderton
• Role of IL-17A in the development of chronic UPEC urinary tract infeciton - Michelle N Chamoun
• Disrupting promoter-enhancer interaction of Bcl11b in T cell by CRISPR/Cas9 - Wing Fuk Chan
• Silencing of immunogenic antigens during adoptive cell therapy is an acquired resistance mediated by complex epigenetic mechanisms - Jonathan CHEE
• Recombinant lipidated survivin is efficiently captured by antigen-presenting cells to trigger antigen cross-presentation and antitumor immunity - Hsin-Wei Chen
• Interplay between Bmp4, Activin βA and Follistatin signalling regulates postnatal thymic epithelial progenitor self-renewal and differentiation - Ann Chidgey
• Phenotypic analysis of T regulatory cells in multiple sclerosis patients - Christopher H.Y. CHIU
• The role of TGFβ in shaping T_RM identity in epithelial and non-epithelial environs - Susan N Christo
• Staphy-PilVax – Can a mucosal vaccine confer protective immunity from Staphylococcus aureus? - Fiona Clow
• MiR-122 induces neutrophilic inflammation in rhinovirus lung infection and asthma exacerbation by targeting SOCS-1 - Adam M Collison
• Induction of th2 immunity by dendritic cells - Lisa Connor
• Integrative analysis of miRNA and mRNA response to human malaria infection using systems immunology - Martha Cooper
• Modulation of murine b cell development during viral encephalitis - Darren A Cox
• A pilot study characterizing the blood transcriptome of neonates during sepsis using RNA-sequencing - Andrew Currie
• CD141⁺ dendritic cells differentiate from human CD34⁺ hematopoietic stem cells in vitro - Ghazal Daraj
• Histone deacetylase 7 is an essential component of macrophage-mediated host defence, promoting phagocytosis, reactive oxygen species production and bacterial clearance - Kaustav Das Gupta
• Identification of generic and pathogen-specific monocyte transcriptomes reveals a largely conserved response in preterm and term newborn infants - Emma de Jong
• Blood components attenuate dendritic cell responses to TLR ligands in an in vitro model of transfusion - Melinda M Dean
• Modulation of leucocyte populations as a result of coronary artery bypass grafting - Melinda M Dean
• Gain-of-function mutations in Pik3cd result in dysregulation of B cells at multiple stages - Elissa K Deenick
• Key characteristics of antigen presenting cells that dictate unconventional T cell immune responses - Tamekha Develyn
• Expression of the skin-homing receptor E-selectin ligand on Herpes Simplex Virus (HSV)-specific CD4 T cells is independent of Th1 differentiation - Shinta T Dewi
• Protection against relapses of disease in a mouse model of multiple sclerosis by a parasite-derived 68-mer peptide - Aakanksha Dixit
• ¹⁸F-FDG-PET: A non-invasive tool for imaging colitis - Nicole Dmochowska
• Agonist immunotherapy restores dysfunctional T cells following MEK inhibition and improves therapeutic efficacy - Sathana Dushyanthen
• A novel allergen-encoding immunotherapeutic vaccine modulates cytokine responses of antigen-specific CD4⁺ T cells in peanut allergy - Preethi Eldi
• The role of the nf-kappaB transcription factor RelA in virtual memory CD8 T cells - Darcy Ellis
• CD4 T cell help promotes the effector CD8 T cell response to hepatocyte-expressed antigens - Kieran English
• Influence of CCL17 on the immune defense against Salmonella infection - Anna Erazo
• A simple, inexpensive cancer immunotherapy: from mouse to Phase I clinical trial - Aude M Fahrer
• Therapeutic implication of Programmed cell death-1 ligand 2 (PD-L2) against Melanoma - Rebecca Faleiro
• Can IL-22 therapy make fatty liver, skinny again? - Saba Farnaghi
• The chemokine receptor CCR2 is critical for protective memory CD8⁺ T cell generation following viral infection - Kevin Aaron Fenix
• Investigating the role of tumour-associated immune cell subsets in human colorectal cancer liver metastasis - Kevin Aaron Fenix
• Disease-associated gut microbiota and circulating metabolites in systemic lupus erythematosus - William A Figgett
• The role of atypical chemokine receptor ACKR4 in melanoma anti-tumour immunity - Jade Foeng
• Suppressing autoimmunity in the CNS with human dental pulp stem cells - Kerrie Foyle
• Antigen-specific memory T cells are regulated by subcutaneous administration of liposomes encapsulating calcitriol and peptide antigen - Ryan Galea
• TGF-β signaling suppresses tumor surveillance by converting conventional NK cells into ILC1s - Yulong Gao
• Donor derived IL-22 is pathogenic following haematopoietic stem cell transplantation - Kate Gartlan
• Investigation of B lymphocyte producing Granzyme B  from breast cancer draining lymph nodes - Abbas A Ghaderi
• Investigating the malaria-specific T cell response in the brains of mice infected with Plasmodium berghei ANKA, the causative agent for experimental cerebral malaria - Nazanin Ghazanfari
• Characterisation of Human MR1-restricted T cells - Nicholas Gherardin
• XCR1 expression by dendritic cells promotes NK cell activation during viral infection - Sonia Ghilas
• Mature extrathymic CD4⁺CD8⁺ T-cells arise from tissue specific CD4⁺ T-cells - Jazmina L Gonzalez Cruz
• Differential glycosylation of the CD8a homodimer regulates binding to the non-classical MHC-I, H2-Q10 - Katharine J Goodall
• An investigation of CD4+ TCR recognition of an immunodominant HIV epitope in controller individuals - Stephanie Gras
• Progesterone signalling at implantation is required for adequate Treg cell tolerance and fetal growth and viability in late-gestation - Ella S Green
• Can autoimmune thyroid disease cause autoimmune attack in the central nervous system (or vice-versa)? - Judith M Greer
• Antibodies specific for myelin proteolipid protein can inhibit remyelination in vivo - Judith M Greer
• Macrophage depletion affects placental labyrinth vascularisation independent of fetal alloantigens - Holly M Groome
• Lymphocyte activation and exhaustion in the natural history of monoclonal gammopathy of undetermined significance - Ewelina Grywalska
• The PD-1/PD-L1 inhibitory pathway is altered in primary glomerulonephritides - preliminary report - Ewelina Grywalska
• Divergent T cell receptor recognition modes of a 13-mer NY-ESO-1 tumour antigenic peptide complexed to HLA-B*07:02 - Benjamin Gully
• Development of human tumour antigen-specific T-cells in a humanised mouse model - Oscar Haigh
• NCOR1 regulates T cell homeostasis and function - Daniela Hainberger
• Killer immunoglobulin-like receptor interactions with human leukocyte antigen ligands are associated with ankylosing spondylitis - Aimee L Hanson
• Multiple luminal factors impair epithelial barrier function and activate colonic sensory nerves in Ulcerative Colitis - Patrick A Hughes
• Bacterial sepsis potentiates hypoxic-ischemic brain injury in neonatal mice - Jacqueline Lai

• The Immunological Journey of an Outsider - Lynn Corcoran