Thursday, 30th November The Australasian Society for Immunology 2017 Annual Scientific Meeting

• The renaissance of antineoplastic immunity from stress response - Yuting Ma
• IL-18 critically drives multiple myeloma progression by generating an immunosuppressive microenvironment. - Mark J Smyth
• Microbiota, immune system and cancer development - Maria Rescigno
• Cellular Immune Therapies: Driving success with lymphoid malignancies to infectious complications, solid cancers and autoimmune diseases - Rajiv Khanna

• Preclinical characterisation of JAK1/JAK2 inhibitors for treatment of type 1 diabetes - Helen E Thomas
• Developments and needs in allergen specific immunotherapy: targeting grass pollen allergy to mitigate the risk of thunderstorm asthma - Janet Davies
• Induction of paralysed dendritic cells with poor immunogenic function following Systemic Inflammatory Response Syndrome (SIRS) - Jose Villadangos
• Identification of a type 1 diabetes associated core microbiome driven by disease associated risk alleles - Emma E Hamilton-Williams

• Programmed Death-1 Ligand 2 Regulates the PD-L1 to PD-1 Axis to Establishing T cell Immunity - Michelle Wykes
• A double dose of a deadly devil cancer - Greg Woods
• Discovering novel immune checkpoint molecules that can be targeted to treat infectious diseases. - Christian Engwerda
• Towards a Systems Understanding of Neonatal Sepsis - Andrew Currie

• Flu and how not to catch it - Marios Koutsakos
• Manipulative Michele and Trustful Thomas: Mast cells activate regulatory B cells - Felix Marsh-Wakefield
• The function of immune cells in patients with a mutation in the DOCK8 gene before and after bone marrow transplant - Bethany A Pillay
• Organ donors; giving more than expected - Amy Prosser
• Immunity at the front line - Erica Wynne-Jones
• Public communications outreach - advances in dendritic cell isolation and research for cancer immunotherapy - Kelly-Anne Masterman

• A novel regulatory network controlling the diversification of the dendritic cell lineages - Michael Chopin
• The atypical chemokine receptor ACKR4 regulates dermal chemokine bioavailability and dendritic cell egress - Cameron Bastow
• Assessment of clonal kinetics reveals multiple trajectories of dendritic cell development - Dawn Lin
• Whole blood human DC immunoprofiling in advanced melanoma patients - Yoke Seng Lee
• Linking adaptive and innate immunity: Covalent binding of Complement C3 to MHC class II molecules regulates dendritic cell development - Patrick Schriek
• Dissecting the molecular mechanisms underpinning T cell help for dendritic cell - Elise Gressier
• Dendritic cell plasticity regulates CD4 T cell differentiation against different pathogens - Johannes U Mayer

• Single cell analysis of self-reactive rogue b-cell clones in autoimmune disease - Joanne H Reed
• Dissecting the “killer module” and its role in Multiple Sclerosis - Margaret A Jordan
• Prostaglandin d2 receptors contribute to lupus pathogenesis by promoting basophils accumulation in secondary lymphoid organs - Christophe Pellefigues
• Reduced cerebral Th17 cell migration confers protection to EAE in DOCK8 deficient mice - Alicia Wilson
• Exploring the importance of antigen conformation in human myelin oligodendrocyte glycoprotein autoantibody binding - Fabienne Brilot
• ChgA-specific liposome treatment of NOD mice prevents T1D progression - Anne-Sophie Bergot
• The glucocorticoid-induced leucine zipper (GILZ): a hurdle for the acquisition of effector functions in leukocytes and a determinant of immune homeostasis - Sarah A Jones

• A viral immunoevasin controls innate immunity by targeting the prototypical natural killer cell receptor family - Richard Berry
• Histone Deacetylase 7 links metabolism and inflammation in macrophages - Melanie R Shakespear
• RP105 drives mycobacteria-induced type I interferon responses - Meg L Donovan
• A novel master adaptor for toll-like receptors tailors pro-inflammatory responses - Lin Luo
• Androgen signaling negatively controls group 2 innate lymphoid cells - Cyril Seillet
• Imaging approaches to understand the effects of bisphosphonate drugs on macrophages outside the skeleton - Marcia A Munoz
• NLRP3 triages danger signals to tailor the immune response to infection and injury - Rebecca C Coll

• IgG-subclass expressing B cells in humans: age-dependent changes and implications for allergen immunotherapy and IgG4-related disease - Menno van Zelm
• Understanding CD8⁺ T cell responses towards the native and alternate HLA-A*02:01-restricted WT1 epitope - Oanh H. O. Nguyen
• Murine LRBA-deficiency causes CTLA-4 deficiency in Tregs without progression to immune dysregulation - Deborah Burnett
• Defective T cell control of Epstein–Barr virus infection in multiple sclerosis - Michael P Pender
• Maintenance of the EBV-specific CD8⁺ TCRab repertoire in immunosuppressed lung transplant recipients - Katherine Kedzierska
• Adoptive cell therapy with CD4⁺ T helper 1 cells and CD8⁺ cytotoxic T cells enhances complete rejection of an established tumour - Sarah Young
• Efficacy of regulatory T cells depletion for the eradication of melanoma by neoantigen-specific CD4 T cells - Elena Shklovskaya

• Identifying novel immune checkpoint molecules that can be targeted to improve CD4⁺ T cell function during chronic infection - Susanna S Ng
• Characterisation of the biochemical signature regulating interaction between CD8aa and the liver expressed non-classical MHC molecule, H2-Q10 - Angela Nguyen
• Characterisation of CD1a-restricted T cells using CD1a-lipid tetramers - Catriona V Nguyen-Robertson
• Altering the immune response to colorectal cancer in mouse models - Ginny Niemi
• Requirement for BAFF-BAFFR signalling in controlling T-dependent B cell responses - Wing Yin Angelica Lau
• CCR2 regulates the magnitude of the CD8+ T cell memory population following viral infection - Todd Norton
• Role of SATB1 in ensuring appropriate transcriptional programs needed for optimal activation and migration of influenza-specific CD8⁺ T cells - Simone Nuessing
• SATB1 shapes T cell fighters for influenza infection - Simone Nuessing
• Association between psoriasis and asthma in the adult general population of United States - Gyeong-Hun Park
• Enhanced activation of human CD141⁺ and CD1c⁺ dendritic cells in vivo with combined TLR3 and TLR7/8 ligation - Ghazal Daraj
• Development of a plasma biomarker profile for tuberculosis - Jessica L Pedersen
• Clarifying the molecular mechanism of STAT3 signaling in naïve and memory B cells - Simon Pelham
• Investigating the role of CD8 T-cells in Rapamycin-mediated regression of squamous cell carcinoma - Nicola Pett
• The functionality of immune cells in DOCK8 deficient patients after haematopoietic stem cell transplant - Bethany A Pillay
• Transplantation of tissue-resident lymphocytes - Amy Prosser
• T cell dysfunction underlies the emerging problem of nontuberculous mycobacterial lung disease - Champa Ratnatunga
• Macrophage coordination of interferon lambda driven inflammation - Scott Read
• Cytotoxic mediator detection from synovial fluid of OA patients - Rangsima Reantragoon
• Regulation of RNA degradation pathways during the LPS response in macrophages - Tara Roberts
• Elucidating the mechanism by which clozapine reduces multiple sclerosis disease - Katharina Robichon
• The interplay between MHC and peptide in identification of self-peptides driving T cell alloreactivity - Louise Rowntree
• Exploring the immunosuppressive potential of venom-derived molecules - Rachael Ryan
• Mapping regulatory networks by chromosome conformation capture in human regulatory T cell - Tim Sadlon
• Mechanisms of resistance of tumours to adoptive cell transfer and vaccination - Tinaz Samiei
• Dissection of CD8⁺ T cell immunodominance hierarchy in human influenza virus infection - Sneha Sant
• To cope with genetic diversity for universal vaccine design: work like Netflix - Sneha Sant
• NF-κB control of innate lymphoid cell development and function in lung inflammation - Sebastian Scheer
• Distinct characteristics of the RP105-agonistic mycobacterial 19 kDa lipoprotein and RP105-mediated macrophage activation - Thomas E Schultz
• Induction of partial T cell exhaustion using combination therapies of antigen-specific intervention and anti-CD3 treatment in NOD mice - Claudia Selck
• Determining T-bet and CXCR3-dependent interactions in Germinal centre function - Amania A. Sheikh
• Investigating the expression of signalling pathways in major immune subtypes in cancer patients - Diana Shinko
• Bach2 is required to sustain the CD4 T cell response - Tom Sidwell
• pDCs or microbial metabolites induce sema4a-mediated treg cell expansion to protect against severe viral bronchiolitis and subsequent asthma - Md. Al Amin Sikder
• Characterisation of the expression and function of the c-type lectin receptor cd302 in mice and humans reveals a role in dendritic cell migration - Pablo Silveira
• Pneumovirus infection induces necroptosis in human bronchial epithelial cells and in a pre-clinical model of bronchiolitis - Jennifer Simpson
• Profiling rogue lymphocytes in autoimmune disease using single-cell multi-omics - Manu Singh
• Blocking protein prenylation in cell culture models of HIDS leads to the formation of NLRP3 inflammasomes by a mechanism dependent on extracellular ATP - Oliver P Skinner
• The protective role of serine 727 phosphorylation of STAT1 in experimental autoimmune encephalomyelitis - Pattama Songkhunawej
• The role of the CD8 co-receptor on MAIT cells - Michael N.T. Souter
• Immunogenicity and protective efficacy of mannosylated liposomes containing inactivated human malaria parasites - Aloysious Ssemaganda
• ADAMTS enzymes, the extracellular matrix and influenza virus immunity - John Stambas
• Early-life respiratory bacterial infection-induced chronic lung disease is driven by a novel TLR2/IL-13/miR-21-dependent, but MyD88-independent signalling pathway   - Malcolm R Starkey
• Vincristine-induced pain: an inflammatory neuropathy - Hana Starobova
• IRF9 prevents CD8⁺ T cell exhaustion in an extrinsic manner during acute LCMV infection - Tamara Suprunenko
• Single cell analysis of the affinity and fate of plasmodium falciparum specific B cells - Henry J Sutton
• Impact of branched-chain amino acid on gut and systemic immune system - Jian Tan
• Measuring human B lymphocyte health in CVID - Jessica C Tempany
• Measuring alterations in intestinal permeability ex-vivo - Amanda Thomson
• Inflammasome activation in primary human monocytes - Sara J Thygesen
• Assessment of human tetanus toxoid-specific memory B cell subsets by flow cytometry using t-distributed stochastic neighbour embedding for data analysis reveals multiple subsets - M. Christian Tjiam
• Rab activation and regulation of TLR4 signalling and inflammation in macrophages - Samuel Tong
• An inhibitor of WNT production improves host control of Listeria monocytogenes - Thao T Tran
• Evaluation of novel nanoemulsion adjuvants (NanoStat^TM) to prevent genital Chlamydia infection and associated pathology   - Logan Trim
• The inflammatory cytokine Oncostatin M is a mediator of neurological heterotopic ossification - Hsu-Wen Tseng
• Postnatal maturation of innate immune functions in human infants: effects of natural versus therapeutic exposure to microbial stimuli - Niamh M Troy
• Initial interactions of Herpes Simplex Virus (HSV) with human skin dendritic cells - Naomi R Truong
• Ultraviolet irradiation of the skin alters the sphingosine-1-phosphate pathway in lymph nodes and blood - Benita Tse
• Differential gene expression in antigen stimulated whole blood from patients with Tuberculosis and Tuberculosis-Diabetes comorbidity - Happy Tshivhula
• Persistent HPV16-related epithelial hyperplasia induces upregulation of immunosuppressive microenvironment - Zewen Kelvin Tuong
• Preventing allergies by inducing tolerance with an epidermal microprojection patch - Nicole van der Burg
• NOD1 sensing of Helicobacter pylori infection mediates processing of pro-interleukin-18 in gastric epithelial cells to maintain tissue homeostasis - Le Son Tran
• Antigen and cytokine induced activation of human naïve T regulatory cells - Christopher H.Y. CHIU
• Rab GTPase Regulation of Macropinocytosis and Toll-like Receptor Signalling in Macrophages - Adam A Wall
• Targeting Interleukin-23(p19) secretion from intestinal epithelial cells to improve intestinal barrier integrity in inflammatory bowel disease - Ran Wang
• Targeting interleukin-23(p19) to improve intestinal barrier integrity in inflammatory bowel disease - Ran Wang
• Investigating the role of T cells in gastric tumour microenvironment - Minyu Wang
• Aussie Gut: Integrated gut microbial and mucosal inflammatory profiling in obesity - Nicholas P West
• Harnessing the molecular pathways invoked following pathogen recognition - Paul G Whitney
• Targeting adult mesenchymal stem cells to the inflamed CNS to ameliorate disease in experimental MS - Jasmine Wilson
• Targeting EBV positive cancers with affinity enhanced T cell receptors - Yide Wong
• Critical role of pDC in regulating gene expression and innate immune responses to human rhinovirus - Yang Xi
• Ablation of PAR1 and PAR2 exacerbates collagen-induced inflammatory arthritis in mice - Meilang Xue
• IFN-γ and IL-27 regulate respiratory syncytial virus-induced asthma exacerbation in a mouse model - Ming Yang
• Targeting interleukin-22 to the pancreas to treat type 2 diabetes mellitus - Grace Yeung
• Nano-adjuvant development for potent therapeutic HPV vaccines - Meihua Yu
• Murine cytomegalovirus degrades MHC II to colonise the salivary glands - Joseph Yunis
• Migration inhibitory factor (MIF) is released following lytic cell death: Possible role as a DAMP - shahrzad zamani
• Screen for inflammasome function amongst NLRPs reveals that NLRP12 is not a bona fide inflammasome nucleator but inhibits the NLRP3 inflammasome - Alina Zamoshnikova
• Structural and mechanistic constraints of an effective antiviral T cell response - Pirooz Zareie
• The role of CD8+ T-cells in the regression of Squamous Cell Carcinoma - Zhen ZENG
• Chlorinated flame retardant dechlorane 602 exacerbates airway inflammation through the regulation of type 2 immune response - Pengcheng Zhou
• Rituximab in multiple sclerosis; Frequency and clinical relevance of anti-drug antibodies - Nicky Dunn
• Impaired control of autoreactive T Cell expansion is associated with pype-1 regulatory T Cell deficiency in BALB/c ZAP70^W163C mutant mice - M Arifur Rahman
• Biological response modifiers in blood products modulate dendritic cell immune responses - Fenny Chong
• In vitro characterisation of anti-major histocompatibility complex class I-mediated transfusion-related acute lung injury (TRALI) - John-Paul Tung
• Activation of naïve CD4⁺CD25⁺FOXP3⁺Treg by autoantigen and Th2 cytokines induces auto-antigen specific Treg - Giang Tran
• Deciphering the molecular mechanism of yin and yang functions of il-33-st2 axis in human cord blood derived mast cells - Pushparaj Peter Natesan
• Decoding the expression profiles of serum cytokines, chemokines and growth factors in Systemic Lupus Erythematosus, using magnetic multiplex immunoassay method, for improving personalized therapeutics - Pushparaj Peter Natesan
• Improving the therapeutic potential of cellular immunotherapies - Dillon Corvino
• Rapid isolation of novel anti-CD3 single chain antibodies via Retained Display library screening technology - Bradley McColl

Immunology as a discipline is dead. The microbiome rules over health and disease, and we all need to become microbiologists.
Affirmative
David Tscharke (Capt)
Anne La Flamme
Simon Barry

Opposition
Phil Hansbro (Capt)
Allison Pettit
Michael Hickey