The ability of Dendritic cells (DCs) to sense and translate environmental cues dictates the fate of the adaptive immune response. The signals provided by allergens and parasites that prime DC to induce T helper 2 (Th2) immunity are not known. Long standing belief suggests that DC prime Th2 responses in the absence of Th1-polarising signals. Recent studies suggest that DCs may require Th2-specific signals from other cell populations such as basophils or innate lymphoid cells, or that distinct DC populations specialise in inducing Th2 immune responses. We sought to identify the specific skin DC populations responsible for inducing Th2 immunity from mice exposed to two distinct Th2 stimuli: Nippostrongylus brasiliensis (Nb) and dibutyl phthalate (DBP)-FITC. In attempt to identify common fate-determining signals, we analysed the DCs transcriptional profiles, surprisingly we found different Th2 stimuli induce highly heterogeneous transcriptional responses by DCs. We identified a type I IFN gene signature induced by Nb but not DBP-FITC and blockade of the IFN pathway impaired Th2 immune responses to Nb but not DBP-FITC. These results suggest that DC are plastic, responding to different environmental cues and multiple mechanisms exist for Th2 priming.