Monday, 27th November The Australasian Society for Immunology 2017 Annual Scientific Meeting

Welcome/ Keynote Introduction - Steve Mattarollo

The renaissance of antineoplastic immunity from stress response - Yuting Ma

• Distinct roles for CD155 in control of tumor growth and metastasis - Indrajit Das

A blood dendritic cell vaccine expands anti-tumour T cell responses in AML - Christian Bryant

Co-chair: Fernando Guimaraes

• ILC1 confer early host protection during viral infection - Joseph Sun
• Rapid loss of group 1 innate lymphoid cells during blood stage Plasmodium infection - Susanna Ng
• Resident and Trafficking Group 1 Innate Lymphoid Cells in Viral Infection - Iona Schuster
• CIS is a potent checkpoint in NK cell-mediated Immunity - Rebecca Delconte

• A brief history of known unknowns:  Gut microbiota derived small molecule and peptide bioactives as extrinsic regulators of mucosal inflammatory tone and homeostasis in inflammatory bowel disease. - Paraic O Cuiv
• Impact of dietary fibre on western lifestyle diseases - Laurence Macia

IL23 secretion from IEC to improve intestinal barrier integrity in IBD - Ran Wang
Multiple luminal factors impair epithelial barrier functiona nd activate colonic - Patrick Hughes
Differential immune responses between animals that clear Group B Streptococcal genital infection and those that remain colonised - Alison Carey
Macrophage depletion affects placental labyrinth vascularisation independent of fetal alloantigens - Holly Groome

• Cancer, chemotherapy and the ageing immune system - Delia Nelson

Skin-resident memory T cells form in the melanoma microenvironment and mediate tumour immune surveillance - Simone L Park

PI3K-δ specific inhibition of regulatory T cells controls metastatic breast cancer via the development of specific anti-tumour T cells - Sarah N Lauder

• Tracking immune cells in cancer using photoconversion and two-photon microscopy - Tatyana Chtanova

Enhanced activation of human CD141+ and CD1c+ dendritic cells in vivo with combined TLR3 and TLR7/8 ligation - Oscar Haigh

Organoid models to investigate novel treatment options for peritoneal metastases from colorectal cancer - Vignesh Narasimhan

• Bacterial evasion of host cell death signaling pathways - Jaclyn Pearson
• Combating the re-emergence of tuberculosis with new vaccine strategies - Andreas Kupz

Novel CD8+ T-cell targets for protection of Indigenous Australians against severe influenza disease - Luca Hensen

Distinct characteristics of the RP105-agonistic mycobacterial 19 kDa lipoprotein and RP105-mediated macrophage activation - Thomas E Schultz

Integrative analysis of miRNA and mRNA response to human malaria infection using systems immunology - Martha Cooper

Histone deacetylase 7 is an essential component of macrophage-mediated host defence, promoting phagocytosis, reactive oxygen species production and bacterial clearance - Kaustav Das Gupta

• Regulation of mucosal inflammation with hookworms - Severine Navarro

The underlying mechanisms during acute viral bronchititis in infants/pre-school children - Anya Jones

Chlorinated Flame retardant exacerbates airway inflammation through type 2 immune response - Pengcheng Zhou

Pneumovirus infection induces necroptosis in human bronchial epithelial cells and in a pre-clinical model of bronchiotis - Jennifer Simpson

• The development of CAR T cell therapy: from the bench to the clinic - Phil Darcy

Targeting local tumour immunosuppression to enhance chimeric antigen receptor T Cell efficacy in solid cancers - Paul A Beavis

Silencing of immunogenic antigens during adoptive cell therapy is an acquired resistance mediated by complex epigenetic mechanisms - Jonathan Chee

• Preventing inflammation and infections by inducing apoptosis. - Thomas Naderer

NOD1 sensing of Helicobacter pylori infection mediates processing of pro-interleukin-18 in gastric epithelial cells to maintain tissue homeostasis - Le Son Tran

Age-related decline in primary CD8 T cell responses is associated with the development of senescence in virtual memory CD8 T cells - Kylie M Quinn

Innate lymphoid cell response to BCG vaccination in mice - Joanna R Kirman

• Targeting the immune system in osteosarcoma - Maya Kansara
• CESTEM-1 clinical trials: using dynamin inhibitors to reverse resistance to monoclonal antibody therapy. - Fiona Simpson

IL-15 dependent melanoma-resident CD8+ T cell numbers predict patient survival and outcome of anti-PD1 therapy - Mainthan Palendira

Therapeutic implication of Programmed cell death-1 ligand 2 (PD-L2) against Melanoma - Rebecca Faleiro

• ILCs- Panning for gold. - Ben Finnin
• Life-threatening infectious diseases of childhood: single-gene inborn errors of immunity? - Jean-Laurent Casanova
• Interaction of the mucosal immune system with the microbiota. - Maria Rescigno

• Where a good start in Immunology (and good mentors), can lead you - Graham Mitchell

• Dissecting the heterogeneity of the human T cell response - Federica Sallusto