Cytokine receptors have a critical role in the pleiotropic function of the immune system through inflammatory signalling pathways, but evidence on their involvement in inherited human immune-dysfunction diseases is accumulating. The interleukin-7 (IL7) and the interleukin-33 (IL-33)-ST2 signalling pathways are typically known to regulate T-lymphocyte development and T-helper type 2 (Th2) response. Variants of the IL7-receptor alpha subunit gene (IL7R, or CD127) are associated with risk for human multiple sclerosis, type-1 diabetes, atopic dermatitis (AD), arthritis, and colitis. Variants in interleukin-1 (IL1)-receptor-like 1 gene (IL1RL1, or ST2) are associated with risk for human asthma, inflammatory bowel disease and AD, as well as asthma and pancreatitis in mice. In view of the homology between gene-sequences of cytokine receptors from dog and human, canine inherited inflammatory diseases may provide novel insights into the roles of interleukins in immune mechanisms. Canine AD is a genetically-linked hypersensitivity with early onset. It shares similar clinical signs with human AD. Our previous work with dogs suffering from AD indicated reduced expression of IL7R and higher risk of AD in mastoid breeds. Elevated serum triglycerides, known as hypertriglyceridemia (hyperTG), are reported in 75% of aged Miniature schnauzer dogs. Similar to human hyperTG, canine hyperTG increases the risk for insulin resistance, pancreatitis, elevated liver enzymes, and gallbladder disease. We investigated functional gene variants of cytokine receptors in dog breeds that are susceptible to these two inflammatory diseases and examined their relative risk of disease. Focusing on IL7R and IL1RL1; Sanger sequencing, restricted-fragment-length-polymorphism (RFLP) and whole-genome-sequence techniques were used to search putative functional variants (IL7Rx3; IL1RL1x3) in exons that have been identified as essential to the function of the receptors. Haplotype and single-marker variant associations with disease status were conducted using PLINK. Cytokine receptor variants may provide fresh insights to the function of interleukin genes in human inflammatory-related diseases.