The induction and activation of Type 2 immune responses is a characteristic feature of infection by helminths and exposure to allergens. We use IL4/IL-13 dual reporter mice to identify the distinct immune cell subtypes that produce Type 2 cytokines during allergic immune responses. We also follow their cytokine expression patterns in the lymph node and skin and lung. We identify that there are quite different IL-4 dependent activation requirements for the development of IL4 and IL-13 Th2 subsets in tissues vs lymph nodes and we discuss the implications of these findings in the context of protective immunity to helminths and reactions associated with allergic diseases.